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Endometrial Receptivity Array (ERA) Test

The Endometrial Receptivity Array (ERA) Test makes it possible to detect and classify the endometrium as receptive or non-receptive, according to the pattern obtained in a fertile woman during the days of the implantation window. In this way, we can calculate the best time to transfer the embryos after an In Vitro Fertilisation.

What is the Endometrial Receptivity Array (ERA) test?

Within a natural ovulation cycle, the endometrium is most receptive for a few specific days after ovulation. This is known as the implantation window, and it is usually located between 19-21 days from the start of the last period (days 5-7 after ovulating). Through the endometrial receptivity array test, it is possible to determine this implantation window, performing an endometrial biopsy during the days that we think are the patient’s implantation window.

Within an in vitro fertilization cycle, before transferring the embryo to the uterus, the endometrium is examined to find out if it is ready for transfer, analyzing the active genes at the time of performing the test and comparing them with the pattern obtained in a fertile woman during the days of the implantation window.

To carry out the analysis, an endometrial biopsy is performed during the days that we think are the patient’s implantation window. This is usually on day 21 of the menstrual cycle (receptive phase) or after 5 full days of Progesterone permeation in a hormone-regulated cycle (HRT).

The gynecologist will take a sample of the endometrial tissue and insert it into a “Cryotube” that allows the tissue sample to be preserved and taken to the laboratory for analysis. The expression of 238 genes involved in endometrial receptivity is analyzed to assess the stage the endometrium is at and to determine if the woman presents a genetic profile of endometrial receptivity at the time of the biopsy. The results of the test are available in approximately 20 days.

This test will indicate if:

  • The endometrium is receptive: The implantation window is located on the day the biopsy was performed and the endometrium is receptive during those days. The transfer of the embryos will be done during those same optimal days for implantation, in a subsequent cycle.
  • The endometrium is not receptive: The endometrium is not receptive during those days. In this case, the analysis may suggest performing a second biopsy by changing the day of sample collection to assess whether the implantation window could be displaced.

For whom is this test indicated?

The endometrial receptivity array test is indicated for

  • Women with an apparently normal uterus and normal endometrial thickness, but who have had repeated implantation failures.
More information
The endometrial receptivity array test allows for each woman a personalized calculation of the best moment to transfer the embryos, trying to coordinate the best moment of the endometrium and the best embryos, to facilitate its implantation.
In assisted reproduction treatments, we often focus on the quality of the embryos, but equally important is the role played by the endometrium, the mucous tissue that lines the inside of the uterus and that will have thickened throughout the menstrual cycle, preparing to receive a possible embryo.

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We started with a lot of fear, because we had all our hopes up and there were a lot of doubts. But little by little, the doctor explained everything to us step by step, and so we started with the treatment and medication, until the day of the transfer finally arrived. And today we are still happily waiting for the arrival of our little boy.
Blanca, Benidorm
On a personal note, I would like to take this moment to thank Dr. Moya. Not only for their exceptional professionalism, but also for a humane treatment that I have rarely, if ever, seen on this long road. We need more people like them.
Belén, Torrevieja
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